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Bioeffect EGF Serum Review: Rejuvenate Your Skin

Bioeffect products are a must-have in a non-invasive skincare regimen. The Bioeffect EGF Serum features the brand’s signature ingredient, EGF (Epidermal Growth Factor), which plays a vital role in producing collagen, elastin, and hyaluronic acid and acts as a gentler alternative to retinol. 

We explore everything you need to know about the Bioeffect EGF Serum, including how it works, tips to achieve the best results, and reviews from our team of estheticians.

The Ingredients & Science Behind Bioeffect EGF Serum

Bioeffect was founded by three Icelandic scientists who developed a bioengineered plant-based growth factor. This growth factor, called EGF (Epidermal Growth Factor), is a signaling protein naturally found in our skin and is Bioeffect’s signature skincare ingredient. 

The groundbreaking Bioeffect EGF Serum features Barley EGF, a skin-rejuvenating, moisture-binding, signaling protein — the first of its kind to be derived from plants. As we age, our skin produces fewer growth factor proteins, and during menopause rapidly depletes, resulting in slower skin cell turnover, sagging, and wrinkles. The science behind the Barley EGF combats these signs of aging by supporting the skin’s natural collagen production, which is essential to keeping skin looking smooth, healthy, and youthful. 

Bioeffect’s Barley EGF is sustainably grown in inert volcanic pumice, using geothermal energy and pure Icelandic water enriched with nutrients. Nestled within the lava fields of Iceland’s Reykjanes Peninsula, The hydroponic, ecologically-engineered greenhouse nurtures up to 130,000 barley plants for their biotech skincare products.

The Bioeffect EGF Serum has only seven pure ingredients. In addition to the Barley EGF, the formula contains hyaluronic acid, glycerin, and pure Icelandic water.

Benefits of Bioeffect EGF Serum

The Bioeffect EGF Serum is gentle enough for anyone to use, even those with sensitive or mature skin. These are the positive effects you could see from using Bioeffect’s award-winning serum.

  • Ability to increase skin thickness
  • Reduces the appearance of fine lines and wrinkles
  • Plumps and improves texture and firmness
  • Boosts hydration and moisture retention
  • Retinol alternative
  • Stimulates collagen and elastin production

How to Use Bioeffect EGF Serum

The Bioeffect EGF Serum is a staple at Joanna Czech studios, with our team using the product during facials and frequently prescribing it for at-home use.

Alessandra Reist, one of our on-staff estheticians, frequently recommends the serum to her clients, sharing, “That with the Bioeffect Serum, it is very important to use on damp skin following toner. Also, a little bit goes a long way - one drop is more than enough for the face and neck (otherwise, it can feel sticky).”

Bioeffect’s website suggests waiting a few minutes for the serum to absorb before applying moisturizer, sunscreen, or makeup. Apply at night for advanced repair while you sleep or during the day to revitalize and hydrate.

Personal Experience and Customer Reviews

Our expert estheticians have been using the Bioeffect EGF Serum for years. Here's their honest feedback and inside advice.

Natalia Kozba from Dallas shares, "After a few uses, you can see the skin looks more plumped, smooth and hydrated. I love it. It's a must-have. Skin looks radiant and is more resilient after using EGF serum."

"The bioeffect serum is fabulous for someone with dehydrated skin as it gives the skin an instant hydration boost! It's also great for plumping up the skin, especially around the laugh lines", says Alessandra.

Lauren Preston from NYC explains the science behind the formula in easy-to-comprehend terms, "The bioeffect serum is a great alternative for people who can't handle a retinoid. It stimulates collagen and elastin production, which aids in restructuring and thickening up the epidermis. In its formula, the humectant glycerin draws in moisture to ensure your skin is plump and well hydrated. It's so gentle. You can use it in the morning and night!"

Final Verdict: Is Bioeffect EGF Serum a Good Product?

The Bioeffect EGF Serum makes a great addition to a non-invasive skincare routine. The formula uses advanced, science-backed ingredients to build a healthy and resilient complexion, following our philosophy of respecting, supporting, and protecting the skin. You don’t need to break down the skin with invasive peels and lasers to see anti-aging results. So, in the end, Bioeffect EGF Serum is Joanna Czech-approved.


Want to try more Bioeffect products? The Imprinting Hydrogel Mask delivers intense moisturization and maximizes the efficacy of Barley EGF, while the Imprinting Eye Masks nourish the delicate eye area. Apply the Bioeffect EGF serum under the masks and roll the Facial Massager over the top for optimum results.